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Fisetin: A novel anti-aging compound specializing in the clearance of senescent cells.

Views: 257     Publish Time: 2025-07-14

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Introduction: A natural substance hidden in strawberries, apples, persimmons (especially Xiangshan red leaves) - Fisetin (Fisetin), discovered by scientists to be a powerful "senescent cells scavenger", has great potential in fighting skin aging and is even called "plant gold"!


It can accurately find and remove those senescent cells in the skin that refuse to leave and keep "poisoning" their neighbors. All-round anti-aging: Not only can it fight senescent cells, but it can also prevent sunburn, fight inflammation, regulate skin immunity, and protect the youthful state of the skin in all directions. 

1. Who is Fisetin? Nature's "Aging cells hunter"! Where does it come from?

It is found in fruits and vegetables such as strawberries (eating 625 grams can get about 100 mg), apples, and persimmons.

It is now mainly extracted from Xiangshan red leaves in China. Core skills: Efficient removal of senescent cells! These cells are like "bad neighbors" in the skin. They stop dividing, do not die, and release harmful substances (SASP) all day long, which drags down the surrounding healthy cells to age, causing the skin to sag and wrinkle. What's so great about it? It can accurately identify and kill about 66% of the skin senescent (such as dermal fibroblasts) without harming normal cells! It can also increase the collagen density in the skin by 41.2%, making the skin tighter! How is it done? It activates the apoptosis pathway of Aging cells and reduces the secretion of harmful substances. 


2.How does fisetin make the skin "reverse aging"? Four ways!

1: Accurately remove senescent cells and make the skin bounce back! Problem: Senescent cells stay in the skin to cause damage, causing the skin to lose elasticity and grow wrinkles.
Fisetin takes action: Like a special forces soldier, it accurately finds and removes about 66% of the skin senescent cells, while stimulating the massive production of collagen (+41.2%), making the skin naturally tighter and more bouncy!


2: Powerful sunscreen to resist "photoaging"! Problem: Sunlight (ultraviolet rays) is the number one culprit of skin aging, causing sunburn, damaging the skin barrier, and causing wrinkles.

Fisetin: Directly "extinguish the fire" of skin cells, cutting the reactive oxygen species ROS caused by ultraviolet rays by half! In animal experiments, it effectively repaired the sunburned skin barrier and reduced the formation of wrinkles by nearly half (45.7%)!
How to prevent it? It can block multiple signal pathways that cause sunburn and aging, reduce inflammation, and enhance the skin's own antioxidant and protective abilities.


3: "extinguish the fire" for the skin, soothing and anti-inflammatory! Problem: The skin will become red, inflamed, and in poor condition when stimulated (such as oxidative stress, inflammatory factors).

Fisetin: It's like pouring a basin of "calming water" on the skin: activating the Nrf2 antioxidant pathway and reducing damage. Effectively suppress the "inflammatory storm" of skin cells, the larger the dose, the stronger the effect! Reduce various inflammatory factors (NO, PGE2, IL-1β, IL-6) and key inflammatory switches (iNOS, COX-2, NF-κB). Result: The skin is calmer and less prone to redness and sensitivity.


4: Regulate skin "immunity" to improve stubborn problems! Problem: Skin problems such as atopic dermatitis, psoriasis, and chronic urticaria are caused by the immune system "fighting indiscriminately", which is difficult to deal with.

Fisetin takes action: cleverly deploy troops: Let overactive immune cells (such as CD4+ T cells) "calm down" (reduce pro-inflammatory factors IFN-γ, IL-4), and at the same time send out "peacekeeping forces" (increase anti-inflammatory factors IL-10), thereby comprehensively improving atopic dermatitis symptoms. 


3.In the study of urticaria and psoriasis, the effect is comparable to or even partially better than commonly used drugs (vitamin D3, rapamycin)!

How to adjust it? Blocks wrong immune signals, reduces inflammation, promotes skin barrier repair, and inhibits the "trigger" (MRGPRX2 receptor) that causes allergies.
We also provide private label supplement with fisetin, Welcome to contact us to know more



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