Bioprodex tm self-assembled nanocapsules release natural herb liver protective active ingredients for maximum efficacy

The following article is from new nutrition, author of nutrition innovation explores evolution

BIOPRODEXTM self-assembly nanocapsules: maximizing the benefits of natural active ingredients

Because of the complex structure of some natural plant components, and the effective components are difficult to dissolve in water, volatile and so on, making its extraction and commercial application become particularly difficult. Although the traditional extraction method can extract some effective components, it is often inefficient and can not meet the needs of enterprises for the effective development of natural products.

In this context, BIOPRODEXTM self-assembled nano-microcapsules technology emerged, no doubt for the extraction and application of natural herbaceous plant provides a new technical solution. This technology can be natural plants, functional oils and fats of the active ingredients efficiently and abundantly delivered to consumers to achieve product diversification.

Compared with the traditional encapsulation technology, BioProdExTM self-assembly nano-microcapsules technology has a larger space for active ingredients, showing a higher load capacity. Thanks to the design of its single-layer structure, hydrophilic substances can be absorbed externally and active substances can be loaded more efficiently internally.

Thus, BioProdExTM self-assembly nanoencapsulation technology has the following advantages:

Enhancing stability and ensuring product safety

It can avoid environmental interference and keep the original characteristics of active components to the greatest extent, so it can improve the stability of the product and reduce the risk of oxidative inactivation.

Promote absorption and enhance bioavailability

Self-assembly protection according to the nature of the extracted components to ensure the stable dispersion of the insoluble components in the aqueous environment, promote the absorption of the active components, and then enhance the Bioavailability.

To overcome the limitation of dissolution and achieve accurate release

Effective release of active ingredients can be ensured in any dosage form, and precise intervention can be achieved by controlling the release rate of active ingredients to reach key locations.

Safe and efficient and enhance utilization efficiency

BIOPRODEXTM self-assembled nanocapsules can achieve almost all the protection of target ingredients, improve the efficiency of effective ingredients, select specific wall materials according to product characteristics, and ensure safety and health, need to Polish and add a price ratio related.

International certification to provide reliable assurance of technology

The technology, which won the Leonardo da Vinci Gold Medal for Invention in 2022, now holds four patents on intellectual property, including two PCT international patents that are pending, it is the guarantee of product quality.

In the pursuit of natural and healthy trends, BioProdExTM self-assembled nano-microcapsules technology for the effective extraction and utilization of plant active ingredients opened up a new world. Taking silymarum and turmeric extracts as examples, this technology also promotes the bioavailability of the products to a new height and plays an indispensable role in the field of liver protection.

Biomtmax TM artichoke extract

Milk Thistle, also known as milk thistle, stands out for its excellent antioxidant properties in the liver-protecting ingredient. The main active component of silybin extract is silybin (50% ~ 70%) . After many pharmacological experiments, Silybin showed strong ability of protecting liver cell membrane, prevention of liver damage caused by various liver toxins has a significant effect on improving liver function [1-4] to protect liver health.

In order to deal with the problems of low bioavailability of silybin, such as poor stability, low water solubility and poor intestinal absorption, BIOPRODEXTM technology encapsulated natural silymarum by nano-self-assembly, the solubility of the product is greatly improved, and the absorption and effectiveness of the product are enhanced.

Nanoscale, improve bioavailability

The particle size of biomtmax TM extract was controlled to 85.3 nm, which increased the contact area with cells and achieved rapid dissolution, and reduced the thickness of the diffusion layer around the active ingredient and increased the concentration gradient, further improve the bioavailability.

Scientific verification, the effect is remarkable

After rigorous experiments, biomtmax TM extract increased the solubility by 43.8 times and the actual entrapment rate was as high as 97.9% , compared with the common extract, the permeability of intestinal cell membrane was increased by 5.13 times in vitro. Compared with overseas brand SILYMARUM extract, the relative inhibition rate of NO on anti-inflammatory cells in vitro was increased by 3.18 times. This data not only proves the strong technical strength, but also shows the excellent performance of the product in the actual application.

BIOCURMAXTM turmeric solid drink

Turmeric also has a place in the liver-protecting market. As a kind of traditional medicinal materials with dual-use of medicine and food, it has been paid more and more attention in the world in recent years. Curcumin is the main active ingredient in its pharmacological action [5-6] , and it also shows amazing potential in the field of liver protection.

However, the absorption and bioavailability of curcumin has been the focus of the market. How to improve the bioavailability of curcumin has become a major challenge for the industry due to its low water solubility, unstable nature and rapid metabolism under physiological and acid-base conditions. The advent of biocurax TM turmeric solid drinks has brought an innovative solution to this problem.

Nanoparticles, more efficient absorption

The particle size of BioCurMaxTM turmeric solid drink is only 129.8 nm. This nanometer-sized particle size, after passing through the gastrointestinal tract, the body retains more and more stable active ingredients, making absorption more efficient.

Strong water solubility and stability

Compared with natural curcumin, BIOCURMAXTM improved the water solubility and stability of the curcumin solid beverage, which was 221 times more water-soluble than the natural curcumin, and the technology also improved the stability of the curcumin formula, at the same pH 1.2, after incubation for 12 hours, the BIOCURCUMA TM Curcuma solid beverage was 19.1 times more stable than natural curcumin.

•15-fold increase in bioavailability

Compared with natural curcumin, biocurcuma MSTM Curcuma solid beverage increased the bioavailability by nearly 15 times.

The ability to fight viruses has been greatly upgraded

BIOCURMAXTM Curcuma solid beverage also showed great potential in antiviral activity. It inhibits up to 80% of viral infections. Notably, BIOCURMAXTM turmeric solid drinks not only prevent viral attachment and infection, but also further inhibit viral replication in infected cells, which also provides a powerful weapon against viral invasion.

Several mature products are under development

Based on BioProdExTM self-assembly embedding technology, several mature products have been successfully launched, including seabuckthorn oil solid drinks (focused on cardiovascular health) , cinnamon oil solid drinks (targeted at reducing uric acid) , angelica root oil solid drinks (female group) , and lycopene solid drinks (male group) , has been widely loved and trusted by consumers.

At the same time, the technology is also actively engaged in more innovative product research and development. In the direction of improving immune function, we are committed to developing ginsenoside microcapsule powder and Ganoderma lucidum triterpene microcapsule powder; in the aspect of body weight management, we are constantly exploring the potential of white kidney bean extract; in the field of anti-alcoholism and liver protection, dihydromyricetin microcapsule powder and puerarin microcapsule powder were designed to protect liver health. In addition, the application of the technology has also expanded from the food field to the field of daily chemicals, through the development of daily products such as resveratrol microcapsules powder, to bring consumers a new skin care experience.

Tech-inno Health: Professional Health product supply chain full case service provider

With the rapid development of modern science and technology, the extraction technology of plant active ingredients has been innovated continuously, and many advanced extraction and separation technologies have been widely used in production practice, thus greatly promoted the rapid development of food and drug analogues and herbaceous components.

Based on more than 20 years of experience in the natural Chinese herbal medicine industry, Tech-inno Health, as a full-service provider in the supply chain of dietary supplement and functional food industries, is well-positioned in the core raw materials, technologies and advantages, adopting the method of data and modularization, it provides strong support for global brand enterprises to develop plant ingredient products efficiently. The company currently has two major production centers -- Guangdong Qingyun Mountain Pharmaceutical Co. , Ltd. and Jiangxi Ganzhou heoluhealth Biotechnology Co. , Ltd. .

Tech-inno health has always adhered to the concept of“Product R & D is the core productivity, technological innovation is the first element of development”, it has set up a future food and health research center of Zhejiang University, a doctor's workstation, natural Chinese herbal medicine extraction and Separation Engineering Research and Development Center, focus on Chinese herbal medicine raw material innovation, technological innovation, health product formulation innovation and category innovation. The raw material database includes 300 kinds of common Chinese herbs, from planting, collecting and processing, from research and development in laboratory to production and testing. At the same time, Tech-inno Health's emphasis on R & D can be seen in the enterprise's annual R & D investment of more than 20 million, are applying for licensing of more than 100 papers, patents, trademarks and other intellectual property.

The invention of BioProdExTM self-assembly encapsulation technology has solved the dosage form problem of natural raw materials in the process of product development and production, it also significantly increased its bioavailability (absorption rate) . This technology can produce raw materials into powder form, which not only greatly improves the convenience of raw materials transportation, but also provides a solid guarantee for the long-term preservation of natural ingredients.

With the help of BioProdExTM self-assembly packaging technology, in addition to broadening the use of raw materials in a variety of scenarios, it can also provide customized services, combining market needs and consumer preferences, from formulation development to formulation application, then to patent endorsement, to meet the needs of different customers to ensure that products with unique and competitive market.

References:

[1] Chan yu-ching, ng wan-kit, Kelly Hu wan-kit. Research progress on pharmacological action of Silybin [ J ] . Shanghai Journal of Traditional Chinese medicine, 2021,55(2) : 90 -96

[2] Zhang Zhipeng, Meng Yanqiu, Wang Ying. Research progress on biological activity and mechanism of action of Silybin and its derivatives [ J ] . Chinese herbal medicine, 2021,52(12) : 3717-3724

[3] Chen Yunhui. Effect of silibinin capsule on liver function and serum lipids in patients with Steatosis disease [ J ] . Straits pharmacy, 23(04)2011:113-114.

[4] Mayer KE, Myers RP, Lee SS. Silymarin treatment of viral hepatitis: a systematic review. J Viral Hepat. 2005 Nov;12(6):559-67.

[5] You Yue, Li Zijian. Pharmacological Action and clinical research progress of curcumin [ J ] . China Science and Technology Information, 2013(14) : 1.

Guo Fang, Gu Zhe, Jia Xieli, etc. . Research progress on medicinal plant curcuma longa [ j ] . Anhui Agricultural Sciences, 2022(016) : 050.

[6] Farooqui T, Farooqui A A. Curcumin: Historical background, chemistry, pharmacological action, and potential therapeutic value[J]. Curcumin for neurological and psychiatric disorders, 2019: 23-44.

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