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What are the healing benefits of raisins?
Views: 417 Publish Time: 2024-09-23
Hovenia dulcis, commonly known as Jujube, is a deciduous tree in the family of Ranunculaceae. Its fleshy fruit stalks have a reddish-brown skin, and the fruit flavor is fragrant, and the sweetness of the fruit is even more intense after the frost. According to the Tang Materia Medica, Materia Medica Compendium, and Lao Lao Heng Yan and other medical writings, Hovenia dulcis relieves coughs and troubles, facilitates urination and defecation, and is the main treatment for headaches, especially to relieve the toxicity of alcohol, and so on.
Modern medical research has shown that Hovenia dulcis contains alkaloids, flavonoids, and triterpenoid saponins, among other active ingredients, which can remove excess free radicals produced in the body after drinking, enhance liver detoxification and enzymology, and accelerate ethanol decomposition and excretion in the body with diuretic effects, reducing the damage of ethanol on the liver tissue and avoiding alcohol poisoning; inhibit lipid peroxidation, and improve the metabolic function of the liver. At the same time, Hovenia dulcis also exhibits a significant anti-fibrotic effect, helping to promote liver cell repair and regeneration.
Hovenia dulcis, as a medicinal plant, has a protective effect on the liver that we can summarize below:
Alcohol detoxification
Hovenia dulcis is able to reduce the concentration of ethanol in the blood, and enhance the activity of the enzyme ethanol dehydrogenase (ADH) in the liver, thus playing an effective role in lowering alcohol consumption. In addition, the Hovenia dulcis dulcis combination has also shown some alcohol detoxification effects, especially in the low dose group where the effects are the best.
Hepatoprotective effect
Ginseng Hovenia dulcis extract has an obvious protective effect on acute alcoholic liver injury, being able to reduce the elevation of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) activity, improve lipid metabolism imbalance, and increase the activity of antioxidant enzymes SOD and GSH-Px. Pueraria dulcis chitosan also has a certain auxiliary protective effect on alcoholic liver injury in mice.
Antioxidant effects
Hovenia dulcis and its extracts can increase liver reduced glutathione (GSH) content and ADH vitality, reduce malondialdehyde (MDA) content, with significant antioxidant effects.
Anti-inflammatory effects
Xiyangshen Hovenia dulcis combination can significantly reduce the acute alcohol intake caused by the serum AST, ALT vitality elevation, reduce the serum TG level and liver tissue MDA content, increase the liver tissue antioxidant enzymes SOD and GSH-Px vitality, inhibit the p-ERK, p-JNK and p-P38 expression, and inhibit apoptosis of hepatocytes.
Improve lipid metabolism
The effects of Pueraria Mirifica, Hovenia dulcis and their dulcis on the blood lipid level and its mechanism of action in mice with acute alcoholic liver injury show that they can significantly improve serum lipid metabolism disorders, inhibit the expression of AQP9, reduce the uptake of glycerol by hepatocytes, improve lipid metabolism, and thus effectively alleviate hepatic steatosis.
Molecular Mechanism
Studies based on network pharmacology and molecular docking technology have shown that the active ingredients in Hovenia dulcis have a better affinity with MAPK1, MAPK3 and AKT1 target proteins, which may be one of the molecular mechanisms for its prevention and treatment of alcoholic liver disease.
ive,anti-angiogenic
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